All kick-off times in GMT.
| 18:30 | Almeria | Las Palmas |
| 18:30 | Atletico Madrid | Sant Andreu |
| 18:30 | Real Betis | Lleida |
| 18:30 | Real Sociedad | Algeciras CF |
| 20:30 | Real Madrid | Olimpic |
| 20:30 | Sevilla FC | Racing Santander |
| 13:00 | Ergotelis | Apollon Smyrni |
| 15:15 | Atromitos | PAOK Salonika |
| 15:15 | FC Xanthi | OFI Crete |
| 15:15 | Panetolikos | Platanias |
| 15:15 | Panthrakikos | Kalloni AEL |
| 17:30 | Levadiakos | Panathinaikos |
| 17:30 | Olympiakos | Giannina |
